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Cl-4AS-1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Cl-4AS-1图片
CAS NO:188589-66-4
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Cl-4AS-1 是一种有效的类固醇雄激素受体(AR)激动剂 (IC50为 12 nM),也是 5α- 还原酶 I 型和 II 型的抑制剂 (IC50分别为 6 和 10 nM)。
生物活性

Cl-4AS-1, a potent steroidalandrogen receptor(AR)agonist (IC50= 12 nM), is also an inhibitor of 5α-reductase types I and II (IC50 = 6 and 10 nM, respectively)[1][2].

IC50& Target

IC50: 12 nM (androgen receptor); 6 nM (5α-reductase types I); 10 nM (5α-reductase types II)[1][2]

体外研究
(In Vitro)

Cl-4AS-1 suppresses MMP-1 promoter activity in 22Rv1 human prostate cancer cells[1].
Cl-4AS-1 (10 μM) effectively promotes the AR N/C interaction, with an average maximal activity of 35.3%[1].

体内研究
(In Vivo)

Cl-4AS-1 produces no significant reduction in prostate weight in intact animals and in castrates rats caused a significant increase of ventral prostate weight[1].

Animal Model:ORX rats[1]
Dosage:10 mg/kg
Administration:I.s.; 7 days
Result:Effect of Cl-4AS-1 on prostate and seminal vesicle growth.
分子量

441.01

Formula

C26H33ClN2O2

CAS 号

188589-66-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.