ACP-105

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ACP-105

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

899821-23-9

包装与价格：

包装	价格(元)
10 mM * 1 mL in DMSO	电议
5mg	电议
10mg	电议
25mg	电议
50mg	电议
100mg	电议
200mg	电议

产品介绍

ACP-105 是一种可口服的、有选择性的、有效的雄激素受体调节剂 (SARM), 其对野生型 AR 和 T877A 突变型 AR 的pEC₅₀值分别为 9.0 和 9.3。

生物活性

ACP-105 is an orally available, selective amd potentandrogen receptormodulator (SARM), withpEC₅₀sof 9.0 and 9.3 for AR wild type and T877A mutant, respectively.

IC₅₀& Target

pEC50: 9.0 (AR wild type), 9.3 (AR T877A mutant)^[1].

体外研究
(In Vitro)

ACP-105 is an orally available, selective amd potent androgen receptor modulator (SARM), with pEC₅₀s of 9.0 and 9.3 for AR wild type and T877A mutant, respectively. The half-lives of ACP-105 (compound 1) in human hepatocytes is measured and found to be 5.0 h^[1].

体内研究
(In Vivo)

ACP-105 enhances freezing in both sham-irradiated and irradiated mice (effect of ACP-105: F=5.44; p=0.028). For MAP-2 immunoreactivity in the cortex of sham-irradiated mice, there is a brain area×ACP-105 interaction (F=6.655; p=0.0027). While ACP-105 reduces MAP-2 immunoreactivity in the sensorymotor cortex, there is a trend towards increased MAP-2 immunoreactivity in the enthorhinal cortex^[2].

分子量

290.79

性状

Solid

Formula

C₁₆H₁₉ClN₂O

CAS 号

899821-23-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : ≥ 103 mg/mL(354.21 mM)

*"≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	3.4389 mL	17.1945 mL	34.3891 mL
5 mM	0.6878 mL	3.4389 mL	6.8778 mL
10 mM	0.3439 mL	1.7195 mL	3.4389 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。