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S-23
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
S-23图片
CAS NO:1010396-29-8
包装与价格:
包装价格(元)
10 mM * 1 mL in DMSO电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
200mg电议
500mg电议

产品介绍
S-23 是一种口服选择性雄激素受体调节剂(SARM)Ki为 1.7 nM。S-23 诱导 CV-1 细胞雄激素受体介导的转录激活。S-23 增加去势大鼠前列腺、精囊和肛提肌重量。
生物活性

S-23 is an orally active selectiveandrogen receptormodulator (SARM) with aKiof 1.7 nM. S-23 inducesandrogen receptor(AR)-mediated transcriptional activation in CV-1 cells. S-23 increases prostate, seminal vesicle, and levator ani muscle weights in castrated rats[1][2].

IC50& Target

Ki: 1.7 nM (Androgen receptor)[1]

体外研究
(In Vitro)

S-23 induces AR-mediated transcriptional activation in CV-1 cells when used at a concentration of 10 nM[1].

体内研究
(In Vivo)

By administration of S-23 to castrated animals, androgen-dependent organ weights increased in a dose-dependent manner. The ED50of S-23 in the prostate and levator ani muscle is 0.43 and 0.079 mg/d, respectively[1].

Animal Model:Male Sprague Dawley rats (in castrated male rats)[1]
Dosage:0.01-3 mg
Administration:S.c.; daily for 14 d
Result:Androgen-dependent organ weights increased in a dose-dependent manner. At a dose rate as low as 0.1 mg/d, S-23 is able to selectively maintain the weight of the levator ani muscle at the intact control level, whereas its effects on the prostate and seminal vesicles are lower than 30% of those observed in intact controls.
分子量

416.75

性状

Solid

Formula

C18H13ClF4N2O3

CAS 号

1010396-29-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month
溶解性数据
In Vitro: 

DMSO : 100 mg/mL(239.95 mM;Need ultrasonic)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM2.3995 mL11.9976 mL23.9952 mL
5 mM0.4799 mL2.3995 mL4.7990 mL
10 mM0.2400 mL1.1998 mL2.3995 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。