CAS NO: | 787504-88-5 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | CSRM617 is a selective small-molecule inhibitor ofthe transcription factor ONECUT2(OC2, a master regulator of androgen receptor) with aKdof 7.43 uM in SPR assays, binding to OC2-HOX domain directly. CSRM617 inducesapoptosisby appearance of cleaved Caspase-3 andPARP. CSRM617 is well tolerated in the prostatecancermouse model[1] |
体外研究 (In Vitro) | CSRM617 (0.01-100 μM; 48 hours) inhibits cell growth in several PC cell lines: PC-3, 22RV1, LNCaP, C4-2 cells[1].CSRM617 (10-20 μM; 48 hours) induces apoptosis in 22Rv1 cells results in cell death in a concentration-dependent fashion[1].CSRM617 (20 μM; 72 hours) induces apoptosis in 22Rv1 cells by appearance of cleaved Caspase-3 and PARP[1]. |
分子量 | 255.23 |
Formula | C10H13N3O5 |
CAS 号 | 787504-88-5 |
运输条件 | Room temperature in continental US; may vary elsewhere. |
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |