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Dexfadrostat
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Dexfadrostat图片
CAS NO:102676-87-9
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
(R)-Fadrozole
(R)-CGS 16949A free base
FAD286
产品介绍
Dexfadrostat ((R)-Fadrozole) 是有效的非甾体类抑制剂。Dexfadrostat 还抑制人胎盘芳香化酶 (pIC50= 6.17) 和醛固酮生物合成。Dexfadrostat 能逆转自发性高血压心力衰竭大鼠的心脏纤维化。
生物活性

Dexfadrostat ((R)-Fadrozole) is a potentnonsteroidalinhibitor[1]. Dexfadrostat also inhibits human placentalaromatase(pIC50= 6.17) and aldosterone biosynthesis. Dexfadrostat reverses cardiac fibrosis in spontaneously hypertensive heart failure rats.[1][2].

IC50& Target

pIC50: 6.17 (human placental aromatase)

体外研究
(In Vitro)

The (-)-enantiomer with the S-absolute configuration was responsible for the high aromatase inhibitory activity of Dexfadrostat[1].

体内研究
(In Vivo)

Dexfadrostat ((R)-fadrozole; 0.24 and 1.2 mg/kg; daily; oral) and (S)-fadrozole similarly decreases plasma aldosterone levels, whereas urinary aldosterone excretion rate was reduced only by S-fadrozole[2].
Dexfadrostat (0.24 and 1.2 mg/kg; daily; oral) effectively reverses preexistent left ventricular interstitial fibrosis by 50% (vs. 42% for canrenoate), S-fadrozole was devoid of an antifibrotic effect[2].

Animal Model:SHHF rats[2]
Dosage:0.24 and 1.2 mg/kg
Administration:Daily; oral
Result:Decreased plasma aldosterone levels and reversed preexistent left ventricular interstitial fibrosis.
分子量

223.27

Formula

C14H13N3

CAS 号

102676-87-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.