CAS NO: | 63676-25-5 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | LY117018, a Raloxifene analog, is a selectiveestrogen receptormodulator. LY117018 exerts antiproliferative effects on breastcancercell lines[1][2]. | ||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | LY117018 (0.01-1000 nM; 24 hours) at lower concentrations (0.01-10 nM) caused an E2-like increase in p53 levels when compared to its effects on cells grown in the stripped medium. At a higher concentration of LY117018 (1 μM), the level of p53 appeared to decline. Treatment with 1 μM LY117018 resulted in a predominantly hypophosphorylated pRb. At lower concentrations, LY117018 did not block E2-induced pRb phosphorylation[1]. Cell Proliferation Assay[2]
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分子量 | 459.56 | ||||||||
Formula | C27H25NO4S | ||||||||
CAS 号 | 63676-25-5 | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |