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LY117018
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
LY117018图片
CAS NO:63676-25-5
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
LY117018,Raloxifene 类似物,是一种选择性雌激素受体(estrogen receptor)调节剂。LY117018 对乳腺癌细胞具有抗增殖作用。
生物活性

LY117018, a Raloxifene analog, is a selectiveestrogen receptormodulator. LY117018 exerts antiproliferative effects on breastcancercell lines[1][2].

IC50& Target[1]

Estrogen receptor

 

体外研究
(In Vitro)

LY117018 (0.01-1000 nM; 24 hours) at lower concentrations (0.01-10 nM) caused an E2-like increase in p53 levels when compared to its effects on cells grown in the stripped medium. At a higher concentration of LY117018 (1 μM), the level of p53 appeared to decline. Treatment with 1 μM LY117018 resulted in a predominantly hypophosphorylated pRb. At lower concentrations, LY117018 did not block E2-induced pRb phosphorylation[1].
LY117018 (1 μM; 96 hours) inhibits MCF-7 cells proliferation with an IC50of 1 μM[2].
LY117018 suppresses oxidative stress-induced endothelial cell apoptosis through activation of ERK1/2 signaling pathway[3].

Cell Proliferation Assay[2]

Cell Line:MCF-7 cells
Concentration:1 μM
Incubation Time:96 hours
Result:Inhibited MCF-7 cells proliferation with an IC50of 1 μM.
分子量

459.56

Formula

C27H25NO4S

CAS 号

63676-25-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.