Ferutinin, a natural terpenoid compound, is anestrogen receptorERαagonist andestrogen ERβ-receptoragonist/antagonist withIC₅₀s of 33.1 nM and 180.5 nM, respectively. Ferutinin acts as an electrogenic Ca²⁺-ionophore that increases calcium permeability of lipid bilayer membranes, mitochondria. Ferutinin possesses estrogenic, antitumor, antibacterial and antiinflammatory activities^[1][2].

Ferutinin manifested antiproliferative activity, inducing apoptosis in several cell types: MCF-7 estrogen-dependent cancer cells, leukemia T-cell line (Jurkat), human and mouse colon carcinoma cells (Caco-2, CT26, HT29), as well as bladder (TCC) cancer cells. Ferutinin potentiates bone mineralization, and is proposed to be used as an antiosteoporosis phytoestrogen^[2].
Ferutinin considerably increases the permeability of artificial and cellular membranes to Ca²⁺-ions and produces apoptotic cell death in different cell lines in a mitochondria-dependent manner. Ferutinin alone (10-60 μM) also dose-dependently dissipated membrane potential. In the presence of Ca²⁺-ions, Ferutinin (10-60 μM) induces considerable depolarization of the inner mitochondrial membrane^[2].

358.47

C₂₂H₃₀O₄

41743-44-6

• Terpenoids
• Sesquiterpenes

• Plants
• Umbelliferae

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