CAS NO: | 569-57-3 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | Chlorotrianisene is a long-acting non-steroidal estrogen and an orally activeestrogen receptormodulator. Chlorotrianisene exhibits antiestrogenic activity. Chlorotrianisene potently inhibits the enzymeCOX-1and inhibits platelet aggregation in whole blood[1][2][3]. | ||||||||||||||||
IC50& Target | Estrogen receptor[1] | ||||||||||||||||
体外研究 (In Vitro) | Comparison of intracellular estrogen receptor (ER) affinities of Chlorotrianisene with respective rat uterine cytosolic ER affinities has initially suggested the potential for activation of ER as a mechanism of growth stimulation. Chlorotrianisene exhibits concentration dependent cell growth stimulation with an EC50of 28 nM and a Kiof 500 nM in MCF-7 cells[1]. | ||||||||||||||||
体内研究 (In Vivo) | The incubation of Chlorotrianisene with rat liver microsomes and NADPH generates a reactive intermediate which binds covalently to proteins. Intermediate may inactivate the uterine estrogen receptors (ER). The incubation of Chlorotrianisene with rat liver microsomes and NADPH in the presence of rat uteri, under conditions which generate intermediate, markedly decreased the binding capacity of the ER for [3H]estradiol (E2)[3]. | ||||||||||||||||
分子量 | 380.86 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C23H21ClO3 | ||||||||||||||||
CAS 号 | 569-57-3 | ||||||||||||||||
中文名称 | 氯丁烯二烯 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 100 mg/mL(262.56 mM;Need ultrasonic) 配制储备液
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