Estrogen receptor modulator1 (compound 18) is an orally active and selectiveestrogen receptormodulator (SERM), with apIC₅₀of 0.46.Estrogen receptor modulator1 induces regression of Tamoxifen-resistant, hormone independent xenograft tumors^[1][2].

Estrogen receptor modulator 1 (compound 18) (100 nM; 10 days) inhibits T47D:A18/PKCα and T47D:A18-TAM1 colony formation^[2].
Estrogen receptor modulator 1 (100 nM; 9 days) significantly inhibits the growth of MCF-7:5C cell, and induces apoptosis in these cells 6 days^[2].

Estrogen receptor modulator 1 (1.5 mg/animal; p.o. ; daily for 2 weeks) results in regression of T47D:A18/PKCα tumors^[2].

242.29

Solid

C₁₄H₁₀O₂S

63676-22-2

Room temperature in continental US; may vary elsewhere.

DMSO : 100 mg/mL(412.73 mM;Need ultrasonic)

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