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Estrogen receptor modulator 1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Estrogen receptor modulator 1图片
CAS NO:63676-22-2
包装与价格:
包装价格(元)
10mg电议
50mg电议
100mg电议

产品介绍
Estrogen receptor modulator 1 (compound 18) 是一种口服活性选择性雌激素受体(estrogen receptor)调节剂 (SERM),pIC50为 0.46。Estrogen receptor modulator 1 诱导 Tamoxifen 耐药、激素非依赖性异种移植瘤的消退。
生物活性

Estrogen receptor modulator1 (compound 18) is an orally active and selectiveestrogen receptormodulator (SERM), with apIC50of 0.46.Estrogen receptor modulator1 induces regression of Tamoxifen-resistant, hormone independent xenograft tumors[1][2].

体外研究
(In Vitro)

Estrogen receptor modulator 1 (compound 18) (100 nM; 10 days) inhibits T47D:A18/PKCα and T47D:A18-TAM1 colony formation[2].
Estrogen receptor modulator 1 (100 nM; 9 days) significantly inhibits the growth of MCF-7:5C cell, and induces apoptosis in these cells 6 days[2].

Cell Proliferation Assay[2]

Cell Line:T47D:A18/PKCα and T47D:A18-TAM1 cells
Concentration:100 nM
Incubation Time:10 days
Result:Inhibit T47D:A18/PKCα and T47D:A18-TAM1 colony formation.

Cell Viability Assay[2]

Cell Line:MCF-7:5C cells
Concentration:100 nM
Incubation Time:9 days
Result:Significantly inhibited the growth of MCF-7:5C cells.
体内研究
(In Vivo)

Estrogen receptor modulator 1 (1.5 mg/animal; p.o. ; daily for 2 weeks) results in regression of T47D:A18/PKCα tumors[2].

Animal Model:4-6 week old athymic mice (Harlan-Sprague-Dawley)[2]
Dosage:1.5 mg/animal
Administration:p.o. ; daily for 2 weeks
Result:Significantly reduced tumor volume.
分子量

242.29

性状

Solid

Formula

C14H10O2S

CAS 号

63676-22-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
In solvent-80°C6 months
-20°C1 month
溶解性数据
In Vitro: 

DMSO : 100 mg/mL(412.73 mM;Need ultrasonic)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM4.1273 mL20.6364 mL41.2729 mL
5 mM0.8255 mL4.1273 mL8.2546 mL
10 mM0.4127 mL2.0636 mL4.1273 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。