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Cholesterol myristate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Cholesterol myristate图片
CAS NO:1989-52-2
包装与价格:
包装价格(元)
250mg电议
500mg电议
1 g电议

产品名称
胆固醇肉豆蔻酸
Cholesteryl Myristate
Cholesteryl tetradecanoate
产品介绍
Cholesterol myristate 是中药中天然类固醇。Cholesterol myristate 与多种离子通道结合,例如nAChRGABAA receptor和内向整流钾离子通道 (potassium ion channel)。
生物活性

Cholesterolmyristate is a natural steroid present in traditional Chinese medicine.Cholesterolmyristate binds to several ion channels such as thenicotinic acetylcholine receptor,GABAA receptor, and the inward-rectifierpotassium ion channel.

IC50& Target

Human Endogenous Metabolite

 

体外研究
(In Vitro)

Mesenchymal stem cells (MSCs) transfected by the Id1 promoter reporter construct, cholesterol myristate increases the activity of Id1 promoter. Cholesterol myristate inhibits the apoptosis of MSCs induced by serum-free. Cholesterol myristate increases the expression of Id1 and its target gene bcl-x/l in MSCs treated with serum-free. Moreover, noggin, a BMP antagonist, reduces the anti-apoptotic effects of cholesterol myristate[1]. Cholesterol myristate inhibits the apoptosis of PC12 cells induced in serum-free condition. Cholesterol myristate significantly increases the expression of BMP4, BMPRIA, p-Smad1/5/8, Id1 and its antiapoptotic target gene Bcl-xL in PC12 cells treated in serum-free condition[1].

分子量

597.01

性状

Solid

Formula

C41H72O2

CAS 号

1989-52-2

中文名称

胆固醇肉豆蔻酸

结构分类
  • Steroids
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month
溶解性数据
In Vitro: 

Ethanol : 3.33 mg/mL(5.58 mM;Need ultrasonic)

H2O :< 0.1 mg/mL(insoluble)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM1.6750 mL8.3751 mL16.7501 mL
5 mM0.3350 mL1.6750 mL3.3500 mL
10 mM---------
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。