Cholesterolmyristate is a natural steroid present in traditional Chinese medicine.Cholesterolmyristate binds to several ion channels such as thenicotinic acetylcholine receptor,GABAA receptor, and the inward-rectifierpotassium ion channel.

Mesenchymal stem cells (MSCs) transfected by the Id1 promoter reporter construct, cholesterol myristate increases the activity of Id1 promoter. Cholesterol myristate inhibits the apoptosis of MSCs induced by serum-free. Cholesterol myristate increases the expression of Id1 and its target gene bcl-x/l in MSCs treated with serum-free. Moreover, noggin, a BMP antagonist, reduces the anti-apoptotic effects of cholesterol myristate^[1]. Cholesterol myristate inhibits the apoptosis of PC12 cells induced in serum-free condition. Cholesterol myristate significantly increases the expression of BMP4, BMPRIA, p-Smad1/5/8, Id1 and its antiapoptotic target gene Bcl-xL in PC12 cells treated in serum-free condition^[1].

597.01

Solid

C₄₁H₇₂O₂

1989-52-2

胆固醇肉豆蔻酸

• Steroids

Room temperature in continental US; may vary elsewhere.

Ethanol : 3.33 mg/mL(5.58 mM;Need ultrasonic)

H₂O :< 0.1 mg/mL(insoluble)

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