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FERb 033
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
FERb 033图片
CAS NO:1111084-78-6
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
FERb 033 是一种选择性和强效的ERβ激动剂 (Ki=7.1 nM,EC50=4.8 nM) ,表现出比对 ERα 62 倍的选择性。
生物活性

FERb 033 is a selective and potentERβagonist (Ki=7.1 nM,EC50=4.8 nM). FERb 033 shows 62-fold selectivity overERα[1].

IC50& Target[1]

ERβ

4.8 nM (EC50)

ERβ

7.1 nM (Ki)

体外研究
(In Vitro)

FERb 033 (0-100 μM) shows specificity on full-length of estrogen receptor (ESR) in transactivation[2].
FERb 033 (10 nM, 2 h) treatment mildly decreases Ca2+response in airway smooth muscle (ASM) cells[3].

Cell Viability Assay[2]

Cell Line:HEK293 cells
Concentration:0-100 μM
Incubation Time:
Result:Induced transcriptional activity via full-length receptor on ERE with EC50values of 0.253 and 0.053 μM for ESR1 and ESR2, respectively.

Cell Viability Assay[3]

Cell Line:ASM cells
Concentration:10 nM
Incubation Time:2 hours
Result:Tended to decrease histamine-elicited Ca2+response in nonasthmatic human ASM cells but not significantly compared to the control.
分子量

281.67

Formula

C13H9ClFNO3

CAS 号

1111084-78-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.