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EMPO
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
EMPO图片
CAS NO:61856-99-3
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍

EMPO is a hydrophilic cyclic nitrone analog of the free radical spin trap DMPO.

Cas No.61856-99-3
别名5-(Ethoxycarbonyl)-5-methyl-1-Pyrroline-N-Oxide
化学名3,4-dihydro-2-methyl-2H-pyrrole-2-carboxylic acid 1-oxide, ethyl ester
Canonical SMILES[O-][N+]1=CCCC1(C)C(OCC)=O
分子式C8H13NO3
分子量171.2
溶解度15 mg/ml in DMSO, 30 mg/ml in DMF, 30 mg/ml in Ethanol
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

EMPO is a hydrophilic cyclic nitrone analog of the free radical spin trap DMPO . The EMPO-superoxide adduct (EMPO-OOH) exhibits an ESR spectrum that is similar to the DMPO-OOH spectrum. [1] However, the EMPO-OOH adduct is about 5-8 times more stable (t1/2 = 4.8 - 8.6 min) and does not spontaneously decay to the hydroxyl adduct, making spectral interpretation less difficult. [1][2][3]

Reference:
[1]. Olive, G., Mercier, A., Le Moigne, F., et al. 2-ethoxycarbonyl-2-methyl-3,4-dihydro-2H-pyrrole-1-oxide: evaluation of the spin trapping properties. Free Radic. Biol. Med. 28(3), 403-408 (2000).
[2]. Stolze, K., Udilova, N., and Nohl, H. Spin adducts of superoxide, alkoxyl, and lipid-derived radicals with EMPO and its derivatives. Biol. Chem. 383(5), 813-820 (2002).
[3]. Zhang, H., Joseph, J., Vasquez-Vivar, J., et al. Detection of superoxide anion using an isotopically labeled nitrone spin trap: Potential biological applications. FEBS Lett. 473(1), 58-62 (2000).