EGTA tetrasodium is a specific calcium ion chelator. EGTA tetrasodium has an apparent calcium dissociation constant (K_d) of 60.5 nM at physiological pH (7.4) and has very high specificity for Ca²⁺over Mg²⁺(Mg²⁺K_d1-10 mM). EGTA tetrasodium significantly inhibits the substrate adherence capacity of inflammatory macrophages^[1][2].

EGTA tetrasodium, proposed as endodontic irrigant, decreases substrate adherence capacity of inflammatory macrophages in a time- and dose-dependent manner. The EGTA tetrasodium concentration that causes an IC₅₀is 202 mM. Chelators react with calcium ions in the hydroxyapatite crystals to produce a metallic chelate. Removal of calcium ions from the dentine makes the dentinal tissue softer, especially the hydroxyapatite-rich peritubular dentin and increases the diameter of exposed dentinal tubules^[2].

468.28

C₁₄H₂₀N₂Na₄O₁₀

13368-13-3

Room temperature in continental US; may vary elsewhere.

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