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Unoprostone
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Unoprostone图片
CAS NO:120373-36-6
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Unoprostone 是一种前列腺素 F2α 类似物 (PGAs),可通过激活BK通道来减少氧化应激和光诱导的视网膜细胞死亡以及吞噬功能障碍。Unoprostone 可以降低眼内压,局部用于青光眼或高眼压症。
生物活性

Unoprostone, a prostaglandin F2α analogs (PGAs), activatesBK channelsto reduce oxidative stress- and light-induced retinal cell death, and phagocytotic dysfunction. Unoprostone reduces intraocular pressure and is used topically for glaucoma or ocular hypertension[1].

体外研究
(In Vitro)

Pretreatment with Unoprostone (0.01, 0.1, 1 μM; 1 h before H2O2treatment) protects against H2O2-induced cell death in a concentration-dependent manner and the effect is significant at 0.1 μM and 1 μM concentrations[1].
Pretreatment with Unoprostone at concentrations of 0.1 to 3 μM protects against light-induced cell death in a concentration-dependent manner; the effect is significant at the 1 and 3 μM concentrations. Unoprostone reduces the morphological change, and it significantly inhibits the low mitochondrial membrane potential and cell death induced by light irradiation[1].
Unoprostone has prostaglandin Freceptors (FP) binding affinity with a Kiof 3.86 μM[2].

Cell Viability Assay[1]

Cell Line:H2O2-induced photoreceptor cell
Concentration:0.01, 0.1, 1 μM
Incubation Time:1 hour before H2O2treatment
Result:Protected against H2O2-induced cell death in a concentration-dependent manner.
体内研究
(In Vivo)

Unoprostone (0.06%, 0.12%; topical instillation; 3 μl) reduces mouse intraocular pressure (IOP) in a dose-dependent manner[3].

Animal Model:Male mice (6 weeks old)[3]
Dosage:0.06%, 0.12%
Administration:Topical instillation; 3 μl
Result:Reduced mouse IOP in a dose-dependent manner.
Clinical Trial
分子量

382.53

Formula

C22H38O5

CAS 号

120373-36-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.