Latanoprost acid

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Latanoprost acid

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

41639-83-2

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

Latanoprost acid 是前列腺素 (PG) F2α 的类似物，是选择性的前列腺素受体FP激动剂，FP 可以特异性激活 FP-PG 受体。Latanoprost acid 通过抑制 ERK，AKT，JNK 和 p38 级联反应，继而沿 c-fos/NFATc1 通路抑制 RANKL 诱导的破骨细胞生成和功能。Latanoprost acid 是一种可降低眼内压力的药物。

生物活性

Latanoprost acid, an analog of prostaglandin (PG) F2α, is an selectiveprostanoid receptor (FP)agonist that specifically activates the FP-PG receptor^[1]. Latanoprost acid inhibits RANKL-induced osteoclastgenesis and function by inhibitingERK,AKT,JNK, and p38 cascade, following by the c-fos/NFATc1 pathway. Latanoprost acid is a medication which works to lower pressure inside the eyes^[2].

IC₅₀& Target^[1]

体外研究
(In Vitro)

Latanoprost acid (10-20 μM;24 hours) reduces he protein expressions of c-fos and NFATc1^[1].
Latanoprost acid (10μM with 50ng/ml RANKL) significantly inhibits ERK, p38, AKT and JNK^[1].
Latanoprost acid (10 μM, 20 μM) significantly inhibits the mature osteoclast formation^[1].

Western Blot Analysis^[1]

Cell Line:	Bone marrow-derived macrophages cells (BMMs)
Concentration:	10 μM, 20 μM
Incubation Time:	24 hours
Result:	Reduced he protein expressions of c-fos and NFATc1.

体内研究
(In Vivo)

Latanoprost acid (i.p.; 20 mg/kg; once a day for 7 days) notably prevents LPS-induced bone destruction at a dose of 20mg/kg^[1].

Animal Model:	8-week-old C57BL/6J mice^[1]
Dosage:	20 mg/kg
Administration:	Intraperitoneally injected; once a day for 7 days
Result:	Notably prevented LPS-induced bone destruction at a dose of 20mg/kg.

分子量

390.51

Formula

C₂₃H₃₄O₅

CAS 号

41639-83-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.