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Latanoprost acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Latanoprost acid图片
CAS NO:41639-83-2
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Latanoprost acid 是前列腺素 (PG) F2α 的类似物,是选择性的前列腺素受体FP激动剂,FP 可以特异性激活 FP-PG 受体。Latanoprost acid 通过抑制 ERK,AKT,JNK 和 p38 级联反应,继而沿 c-fos/NFATc1 通路抑制 RANKL 诱导的破骨细胞生成和功能。Latanoprost acid 是一种可降低眼内压力的药物。
生物活性

Latanoprost acid, an analog of prostaglandin (PG) F2α, is an selectiveprostanoid receptor (FP)agonist that specifically activates the FP-PG receptor[1]. Latanoprost acid inhibits RANKL-induced osteoclastgenesis and function by inhibitingERK,AKT,JNK, and p38 cascade, following by the c-fos/NFATc1 pathway. Latanoprost acid is a medication which works to lower pressure inside the eyes[2].

IC50& Target[1]

FP

 

体外研究
(In Vitro)

Latanoprost acid (10-20 μM;24 hours) reduces he protein expressions of c-fos and NFATc1[1].
Latanoprost acid (10μM with 50ng/ml RANKL) significantly inhibits ERK, p38, AKT and JNK[1].
Latanoprost acid (10 μM, 20 μM) significantly inhibits the mature osteoclast formation[1].

Western Blot Analysis[1]

Cell Line:Bone marrow-derived macrophages cells (BMMs)
Concentration:10 μM, 20 μM
Incubation Time:24 hours
Result:Reduced he protein expressions of c-fos and NFATc1.
体内研究
(In Vivo)

Latanoprost acid (i.p.; 20 mg/kg; once a day for 7 days) notably prevents LPS-induced bone destruction at a dose of 20mg/kg[1].

Animal Model:8-week-old C57BL/6J mice[1]
Dosage:20 mg/kg
Administration:Intraperitoneally injected; once a day for 7 days
Result:Notably prevented LPS-induced bone destruction at a dose of 20mg/kg.
分子量

390.51

Formula

C23H34O5

CAS 号

41639-83-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.