包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | cis-4-Br-2,5-F2-PCPA (S1024) is a selective inhibitor oflysine-specific demethylase 1(LSD1), with aKivalue of 94 nM instead of 8.4 μM forLSD2. There is aberrant expression ofLSD1incancer stem cells, cis-4-Br-2,5-F2-PCPA inhibitsLSD1cell proliferation and by increasing the level of dimethylated histone H3 at K4 (H3K4) in CCRF-CEM cells[1]. | ||||||||
IC50& Target | Ki: 94 nM (LSD1); 8.4 μM (LSD2)[1] | ||||||||
体外研究 (In Vitro) | cis-4-Br-2,5-F2-PCPA (compound 7c) inhibits proliferation of the T-cell acute lymphoblastic leukemia (T-ALL) with IC50s of 12 μM (CCRF-CEM) and 16 μM (Jurkat), respectively, without inhibiting the human normal fibroblast cell line WI-38[1]. Western Blot Analysis[1]
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分子量 | 248.07 | ||||||||
Formula | C9H8BrF2N | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |