您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > A2-Iso5-2DC18
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
A2-Iso5-2DC18
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
A2-Iso5-2DC18图片
CAS NO:2412492-07-8
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
A2-Iso5-2DC18 是一种二氢咪唑连接脂类,是一种强效的 mRNA 传递载体。A2-Iso5-2DC18 能够用于包括 B16F10 黑色素瘤在内的抗肿瘤的研究。
生物活性

A2-Iso5-2DC18 is a dihydroimidazole-linked lipid, served as potent mRNA delivery vehicle. A2-Iso5-2DC18 can be used for antitumor research, including B16F10 melanoma.[1].

体内研究
(In Vivo)

A2-Iso5-2DC18, loaded with mLuc or Cre-recombinase mRNA LNPs (mCre), (0.1 mg/kg and 0.5 mg/kg; s.c.; once a week, for 2 weeks) transfects central antigen presenting cells (APCs) in A14/Cre mRNA mouse model[1].
A2-Iso5-2DC18 loaded with OVA mRNA (mOVA) vaccine, (15 μg mOVA per mouse; s.c.; twice dose, once every 5 d) induces a significantly high antigen-specific cytotoxic T lymphocyte (CTL) response, in parallel with robust IFN-? secretion in B16F10 mouse melanoma model[1].

Animal Model:A14/Cre mRNA mouse model (female B6 mice)[1]
Dosage:Loaded with Cre-recombinase mRNA LNPs (mCre); 0.1 mg/kg and 0.5 mg/kg
Administration:Subcutaneous injection; 3 weeks
Result:Induced protein expression in the local injection site and the draining lymph nodes and transfected central antigen presenting cells (APCs) including macrophages/monocytes (CD11b+) and dendritic cells (CD11c+) in mice.
Animal Model:Ovalbumin (OVA)-expressing B16F10 mouse melanoma model[1]
Dosage:Loaded with OVA mRNA (mOVA) vaccine; 15 μg mOVA per mouse
Administration:Subcutaneous injection; once per week for the first two weeks; 3 weeks continuous observation
Result:Significantly decreased tumor volume of B16-OVA melanoma and improved overall survival in mice.
Increased the number of systemic and tumor-infiltrating antigen-specific T cells dramatically (20–30-fold).
分子量

726.21

Formula

C47H87N3O2

CAS 号

2412492-07-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.