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Talarozole(R enantiomer)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Talarozole(R enantiomer)图片
CAS NO:870093-23-5
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
(R)-Talarozole
产品介绍
Talarozole R enantiomer是一个强的,有选择性的细胞色素P450,CYP26的抑制剂。
生物活性

Talarozole R enantiomer is a potent and selective inhibitor ofcytochrome P45026-mediated breakdown of endogenous all-trans retinoic acid for the treatment of psoriasis and acne. Target:CYP26in vitro: Talarozole R enantiomer treatment increased the mRNA expression of CRABP2, KRT4, CYP26A1 and CYP26B1 dose dependently, and decreased theexpression of KRT2 and IL-1alpha compared with vehicle-treated skin. No mRNA change in retinol-metabolizing enzymes was obtained. There was no induction of epidermal thickness or overt skin inflammation in talarozole-treated skin. Immunofluorescence analysis confirmed an upregulation of KRT4 protein, but no upregulation of CYP26A1 and CYP26B1 expression was detected [1] [2]. in vivo: Talarozole R enantiomer slightly diffused into the skin only when dissolved in propylene glycol, isopropyl myristate or ethanol. Although only 0.1% of the dose applied was found in the skin itself after 12-24 h, this was sufficient to achieve local concentrations well above the half-maximal inhibitory concentration value for talarozole. The distribution of talarozole within the skin was investigated: 80% was located in the epidermis, while the remaining 20% was found in the dermis [3].

分子量

377.51

Formula

C21H23N5S

CAS 号

870093-23-5

中文名称

(R)-他拉罗唑

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

溶解性数据
In Vitro: 

DMSO : ≥ 51 mg/mL(135.10 mM)

*"≥" means soluble, but saturation unknown.

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM2.6489 mL13.2447 mL26.4894 mL
5 mM0.5298 mL2.6489 mL5.2979 mL
10 mM0.2649 mL1.3245 mL2.6489 mL