| CAS NO: | 9063-57-4 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| Cas No. | 9063-57-4 |
| Canonical SMILES | Thr-Lys-Pro-Arg |
| 分子式 | C21H40N8O6 |
| 分子量 | 500.59 |
| 溶解度 | Water : ≥ 160 mg/mL (319.62 mM) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Tuftsin is a tetrapeptide. Tuftsin is a macrophage/microglial activator. Tuftsin is a tetrapeptide, Thr-Lys-Pro-Arg, which resides in the Fc-domain of the heavy chain of immunoglobulin G. Tuftsin possesses a broad spectrum of activities related primarily to the immune system function and exerts on phagocytic cells, notably on macrophages. Tuftsin's capacity to augment cellular activation is mediated by specific receptors that are identified, characterized, and recently isolated from rabbit peritoneal granulocytes[1]. Tuftsin, a macrophage/microglial activator, dramatically improves the clinical course of experimental autoimmune encephalomyelitis (EAE), a well-established animal model for MS. Tuftsin administration correlates with upregulation of the immunosuppressive Helper-2 Tcell (Th2) cytokine transcription factor GATA-3. Tuftsin promotes phagocytic activity for cells of monocytic origin, such as neutrophils, macrophages and microglia, all of which are thought to express Tuftsin receptors[2]. [1]. Fridkin M, et al. Tuftsin: its chemistry, biology, and clinical potential. Crit Rev Biochem Mol Biol. 1989;24(1):1-40. [2]. Wu M, et al. Tuftsin promotes an anti-inflammatory switch and attenuates symptoms in experimentalautoimmune encephalomyelitis. PLoS One. 2012;7(4):e34933. |
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