CAS NO: | 1854901-94-2 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | TAK-828F is a potent, selective, and orally available retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonist (bindingIC50=1.9 nM, reporter geneIC50=6.1 nM). TAK-828F shows excellent RORγt isoforms selectivity (>5000-fold selectivity against humanRORαand RORβ)[1]. | ||||||||
IC50& Target | IC50: 1.9 nM (RORγt, binding IC50), 6.1 nM (RORγt, reporter gene IC50)[1] | ||||||||
体内研究 (In Vivo) | TAK-828F (0.3, 1, and 3 mg/kg; orally administered; b.i.d.; 28 days; in mice with IL-23-induced cytokine expression model) shows robust and dose-dependent inhibition of IL-17A expression with an ED80of 0.5 mg/kg[1].
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分子量 | 509.57 | ||||||||
Formula | C28H32FN3O5 | ||||||||
CAS 号 | 1854901-94-2 | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |