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DPP-IV-IN-1
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
DPP-IV-IN-1图片
CAS NO:625110-37-4
包装与价格：
包装价格(元)
5mg电议
10mg电议

产品介绍
DPP-IV-IN-1是一种有效的dipeptidylpeptidaseIV(DPP-IV)抑制剂，IC50值为4.6nM；DPP-IV为一种特异性的丝氨酸蛋白酶(serineprotease)。
Cas No.625110-37-4
Canonical SMILESN#C[C@H]1N(C(CNC(C)(C)CO)=O)C[C@@H](F)C1
分子式C11H18FN3O2
分子量243.28
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

DPP-IV-IN-1 is a potent inhibitor of dipeptidyl peptidase IV (DPP-IV), a highly specific serine protease, with an IC50 of 4.6 nM.

DPP-IV-IN-1 (0.1 and 0.3 mg/kg, p.o.) reduces the increase in plasma glucose beginning 30 min after glucose loading, and significantly suppresses hyperglycemia at the dose of 0.3 mg/kg in a rat model of obesity and impaired glucose tolerance. The effect is based on its inhibitory effect on plasma DPP-IV activity[1].

[1]. Fukushima H, et al. Synthesis and structure-activity relationships of potent 4-fluoro-2-cyanopyrrolidine dipeptidyl peptidase IV inhibitors. Bioorg Med Chem. 2008 Apr 1;16(7):4093-106.