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Dutogliptin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Dutogliptin图片
CAS NO:852329-66-9
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Dutogliptin是一种口服有效的选择性二肽基肽酶-4(DPP4)抑制剂。
Cas No.852329-66-9
别名杜拓格利普汀,PHX-1149 free base
Canonical SMILESO=C(CN[C@@H]1CCNC1)N(CCC2)[C@@H]2B(O)O
分子式C10H20BN3O3
分子量241.1
溶解度DMSO: 300 mg/mL (1244.30 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Dutogliptin is an orally available, potent, and selective dipeptidyl peptidase-4 (DPP4) inhibitor.

Dutogliptin is highly water soluble (>2000 mg/mL), has low cellular permeability, exhibits low plasma protein binding (11%) and is rapidly absorbed with a Tmax of 3-4 h and a half-life of 10-13 h. The compound is metabolically stable and does not inhibit or induce the activity of major CYP450s[2].

[1]. Marier JF, et al. Population pharmacokinetic analysis of dutogliptin, a selective dipeptidyl peptidase-4 inhibitor. Clin Pharmacol Drug Dev. 2014 Jul;3(4):297-304. [2]. Pattzi HM, et al. Dutogliptin, a selective DPP4 inhibitor, improves glycaemic control in patients with type 2 diabetes: a 12-week, double-blind, randomized, placebo-controlled, multicentre trial. Diabetes Obes Metab. 2010 Apr;12(4):348-55.