CAS NO: | 19685-09-7 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | (S)-10-Hydroxycamptothecin (10-HCPT;10-Hydroxycamptothecin) is aDNAtopoisomeraseIinhibitor of isolated from the Chinese plantCamptotheca accuminata. (S)-10-Hydroxycamptothecin exhibits a remarkableapoptosis-inducing effect. (S)-10-Hydroxycamptothecin has the potential for hepatoma, gastric carcinoma, coloncancerand leukaemia treatment[1][2][3][4]. | ||||||||||||||||
IC50& Target[1][3] |
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体外研究 (In Vitro) | (S)-10-Hydroxycamptothecin (5-20 μg/L; 6 days; Hep G2 cells) treatment results in the cell cycle arrest at G2/M phase[2]. Cell Cycle Analysis[2]
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体内研究 (In Vivo) | (S)-10-Hydroxycamptothecin (10-Hydroxycamptothecin) against L1210 leukemia in mice is tested. At the optimal dose (15 mg/kg), (S)-10-Hydroxycamptothecin has a 71% increase in life span (ILS)[1]. | ||||||||||||||||
分子量 | 364.35 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C20H16N2O5 | ||||||||||||||||
CAS 号 | 19685-09-7 | ||||||||||||||||
中文名称 | 10-羟基喜树碱;(S)-10-羟基喜树碱 | ||||||||||||||||
结构分类 |
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来源 |
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运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) | ||||||||||||||||
溶解性数据 | In Vitro: DMSO : 50 mg/mL(137.23 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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