CAS NO: | 130-86-9 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | Protopine, an isoquinoline alkaloid contained inplantsin northeast Asia. IC50 Value: Target: In vitro: Protopine was found to reduce nitric oxide (NO), cyclooxygenase-2 (COX-2), and prostaglandin E(2) (PGE(2)) production by LPS-stimulated Raw 264.7 cells, without a cytotoxic effect. Pre-treatment of Raw 264.7 cells with protopine reduced the production of pro-inflammatory cytokines [2]. Protopine is a novel microtubule stabilizer with anticancer activity in HRPC cells through apoptotic pathway by modulatingCdk1activity andBcl-2 familyof proteins [3]. In HepG2 cells, protopine significantly increased CYP1A1 mRNA levels after 24h exposure at concentrations from 25 and 10 μM. Protopine also dose-dependently increased CYP1A1 and CYP1A2 mRNA levels in human hepatocytes [4]. In vivo: Assays were performed on MDA-MB-231 human breastcancercells, and the result showed that protopine exhibited anti-adhesive and anti-invasion effects in MDA-MB-231 cells; after treatment with protopine for 90 min, the expression ofEGFR, ICAM-1, αv-integrin, β1-integrin and β5-integrin were remarkably reduced [1]. | ||||||||||||||||
分子量 | 353.37 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C20H19NO5 | ||||||||||||||||
CAS 号 | 130-86-9 | ||||||||||||||||
中文名称 | 原阿片碱;双花母草素;全能花素 | ||||||||||||||||
结构分类 |
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来源 |
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运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 12.5 mg/mL(35.37 mM;ultrasonic and warming and heat to 60℃) 配制储备液
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