CAS NO: | 518-17-2 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
1 g | 电议 |
生物活性 | Evodiamine is an alkaloid isolated from the fruit ofEvodia rutaecarpaBentham with diverse biological activities including anti-inflammatory, anti-obesity, and antitumor. | ||||||||||||||||
体外研究 (In Vitro) | Evodiamine shows cytotoxicity against a variety of human cancer cell-lines by inducing apoptosis. Moreover, it is a naturally multi-targeting antitumor molecule, which exerts the antitumor activity by various molecular mechanism such as caspase-dependent and -independent pathways, sphingomyelin pathway, calcium/JNK signaling, 31 PI3K/Akt/caspase and Fas-L/NF-κB signaling pathways32[1]. | ||||||||||||||||
体内研究 (In Vivo) | Evodiamine inhibits the metabolism of dapoxetine. Compared to the control group, the pharmacokinetic parameter of t1/2, AUC(0-∞) and Tmax of dapoxetine in evodiamine group is significantly increased by 63.3%, 44.8% and 50.4%, respectively. Moreover, evodiamine has significantly decreased the pharmacokinetic parameter of t1/2 and AUC(0-∞) of desmethyl dapoxetine[2]. Evodiamine suppresses tumor growth in a subcutaneous H22 xenograft model. Evodiamine attenuates VEGF-induced angiogenesisin vivo[3]. | ||||||||||||||||
分子量 | 303.36 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C19H17N3O | ||||||||||||||||
CAS 号 | 518-17-2 | ||||||||||||||||
中文名称 | 吴茱萸碱;吴茱萸胺 | ||||||||||||||||
结构分类 |
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来源 |
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运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 10 mg/mL(32.96 mM;Need ultrasonic) 配制储备液
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