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Asp-AMS
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Asp-AMS图片
CAS NO:828288-98-8
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
25mg电议

产品介绍
Asp-AMS是天冬氨酸腺苷酸的一个类似物，是aspartyl-tRNA合成酶(aspartyl-tRNAsynthetase)的一个抑制剂，也是线粒体酶(mitochondrialenzyme)的强效竞争性抑制剂。
Cas No.828288-98-8
Canonical SMILESO[C@@H]([C@H]([C@H](N1C=NC2=C1N=CN=C2N)O3)O)[C@H]3COS(=O)(NC([C@@H](N)CC(O)=O)=O)=O
分子式C14H19N7O9S
分子量461.41
溶解度DMSO : ≥ 100 mg/mL (216.73 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Asp-AMS, an analogue of aspartyl-adenylate, is an aspartyl-tRNA synthetase inhibitor and also a strong competitive inhibitor of the mitochondrial enzyme.

Asp-AMS is a 500-fold stronger competitive inhibitor of the mitochondrial enzyme than aspartol-AMP (10 nM) and a 35-fold lower competitor of human and bovine cyt-AspRSs (300 nM). Asp-AMS is a strong inhibitor with Ki in the nanomolar (nM) range. Asp-AMS has also the highest inhibitory effect for the mitochondrial enzyme. Asp-AMS is the most active inhibitor with Ki values in the nanomolar range, with a stronger effect on bacterial AspRSs (E. coli and P. aeruginosa) than on human cytosolic AspRS[1].

[1]. Messmer M, et al. Peculiar inhibition of human mitochondrial aspartyl-tRNA synthetase by adenylate analogs. Biochimie. 2009 May;91(5):596-603.