Sabinene 是一种天然双环单萜化合物，可作为香料、香料添加剂、精细化学品和高级生物燃料。Sabinene 也是一种具有口服活性的化合物，可减轻骨骼肌萎缩，调节 ROS 介导的 MAPK/MuRF-1 通路。
| 生物活性 | Sabinene is an naturally occurring bicyclic monoterpene which can be used as flavorings, perfume additives, fine chemicals, and advanced biofuels. Sabinene is also an orally active compound to attenuates skeletal muscle atrophy and regulates ROS-mediated MAPK/MuRF-1 pathways[1][2]. |
体外研究
(In Vitro) | Sabinene (10-300 μM; 18 h) induces predominant recovery of reductions of myotube diameters under starvation[2].
Sabinene (300 μM; 18 h) diminishes the elevated E3 ubiquitin ligase muscle ring-finger protein-1 (MuRF-1) expression and p38 mitogen-activated protein kinase (MAPK), and attenuates extracellular signal-regulated kinase1/2 (ERK1/2) phosphorylations in starved myotubes[2].
Sabinene (300 μM; 18 h) decreases the increased level of reactive oxygen species (ROS) in myotubes under starvation[2].
Cell Cytotoxicity Assay[2] | Cell Line: | IL-6 myoblasts | | Concentration: | 300 μM | | Incubation Time: | 18 and 48 hours | | Result: | Failed to affect the viability of IL-6 myoblasts after 48 h incubation and recovered more than 50% of starvation-induced myoblast atrophy after 18 h. |
Western Blot Analysis[2] | Cell Line: | IL-6 myoblasts | | Concentration: | 300 μM | | Incubation Time: | 18 hours | | Result: | Attenuated muscle atrophy-related signaling proteins phosphorylation in starved myotubes. |
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体内研究
(In Vivo) | Sabinene (6.4 mg/kg; p.o.; once daily; during the fasting for 2 d) attenuates skeletal muscle atrophy by regulating the activation mechanism of ROS-mediated MAPK/MuRF-1 pathways in starved myotubes, probably leading to the reverse of reduced muscle fiber size in fasted rats[2].
| Animal Model: | Fasted animal model in rat[2] | | Dosage: | 6.4 mg/kg | | Administration: | Oral gavage; once daily; during the fasting for 2 days | | Result: | Reduced the levels of muscle fiber atrophy and MuRF-1 expression in gastrocnemius from fasted rats. |
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| 结构分类 | - Terpenoids
- Other Monoterpenes
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | | Pure form | -20°C | 3 years | | 4°C | 2 years | | In solvent | -80°C | 6 months | | -20°C | 1 month |
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| 溶解性数据 | In Vitro: DMSO : 33.33 mg/mL(244.66 mM;Need ultrasonic) 配制储备液 | 1 mM | 7.3405 mL | 36.7026 mL | 73.4053 mL | | 5 mM | 1.4681 mL | 7.3405 mL | 14.6811 mL | | 10 mM | 0.7341 mL | 3.6703 mL | 7.3405 mL |
*请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。 |
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