CAS NO: | 1258-84-0 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
生物活性 | Pristimerin is a potent and reversible monoacylglycerol lipase (MGL) inhibitor with anIC50of 93 nM. | ||||||||||||||||
IC50& Target | IC50: 93 nM (MGL)[1] | ||||||||||||||||
体外研究 (In Vitro) | Pristimerin inhibits the activity of purified MGL with an IC50of 93±8 nM and that of non-purified MGL (cell lysates of MGL-transfected HeLa cells) with an IC50of 398±68 nM. Pristimerin inhibits MGL through a mechanism that is rapid, reversible and non-competitive. The binding of pristimerin to MGL might be strengthened by formation of a polar interaction with a regulatory cysteine, possibly Cys208[1]. Pristimerin inhibits HFLS-RA and HUVEC cell viability in a dose- and time-dependent manner. Pristimerin decreases VEGF-induced autophosphorylation of VEGFR2 and attenuates the activation of the VEGF-induced VEGFR2-mediated signaling pathway[2]. | ||||||||||||||||
体内研究 (In Vivo) | Pristimerin inhibits inflammation and tumor angiogenesis. Pristimerin significantly reduces vessel density in synovial membrane tissues of inflamed joints and reduces the expression of pro-angiogenic factors in sera, including TNF-α, Ang-1, and MMP-9[2]. | ||||||||||||||||
分子量 | 464.64 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C30H40O4 | ||||||||||||||||
CAS 号 | 1258-84-0 | ||||||||||||||||
中文名称 | 扁蒴藤素 | ||||||||||||||||
结构分类 |
| ||||||||||||||||
来源 |
| ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
| ||||||||||||||||
溶解性数据 | In Vitro: DMF : 25 mg/mL(53.81 mM;Need ultrasonic) DMSO : 20 mg/mL(43.04 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
*以上所有助溶剂都可在本网站选购。 |