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Coenzyme Q9
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Coenzyme Q9图片
CAS NO:303-97-9
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议
100mg电议

产品名称
辅酶Q9
Ubiquinone Q9
CoQ9
Ubiquinone 9
产品介绍
Coenzyme Q9 (Ubiquinone Q9) 是啮齿类动物泛醌的主要形式,是电子传递链中的一种双亲分子组分,具有内源性抗氧化剂的作用。Coenzyme Q9 可减轻糖尿病引起的抗氧化防御机制的下降。Coenzyme Q9 改善左心室功能,减少心肌梗死面积和心肌细胞凋亡。
生物活性

Coenzyme Q9 (Ubiquinone Q9), the major form of ubiquinone in rodents, is an amphipathic molecular component of the electron transport chain that functions as an endogenous antioxidant. Coenzyme Q9 attenuates the diabetes-induced decreases in antioxidant defense mechanisms. Coenzyme Q9 improves left ventricular performance and reduces myocardial infarct size and cardiomyocyteapoptosis[1][2].

IC50& Target

Human Endogenous Metabolite

 

体内研究
(In Vivo)

Coenzyme Q9 (5 mg/kg; p.o.; once a day for 4 weeks) reduces myocardial ischemia/reperfusion injury[2].
CoQ10and CoQ9are components of themitochondrial respiratory chain in mammals and can regulate some mitochondrial proteins/functions. Soybean, corn, and rapeseed oils are very rich sources of CoQ10, whereas CoQ9has been found in high concentrations in corn oil[3].
The lack of a functional CoQ9protein in homozygous CoQ9mutant (CoQ9(X/X)) mice causes a severe reduction in the CoQ7protein and a widespread CoQ deficiency and accumulation of demethoxyubiquinone. The deficit in CoQ induces a brain-specific impairment of mitochondrial bioenergetics performance, a reduction in respiratory control ratio, ATP levels and ATP/ADP ratio and specific loss of respiratory complex I. These effects lead to neuronal death and demyelinization with severe vacuolization and astrogliosis in the brain of CoQ9(X/X) mice that consequently die between 3 and 6 months of age[4].

Animal Model:Male Hartley guinea pigs of about 350-400 g body weight[2]
Dosage:5 mg/kg of body weight
Administration:P.o.; once a day for 4 weeks
Result:Nutritional supplementation of CoQ9 can reduce myocardial ischemia/reperfusion injury to the same extent as CoQ10.
分子量

795.23

性状

Solid

Formula

C54H82O4

CAS 号

303-97-9

中文名称

辅酶Q9

结构分类
  • Quinones
  • Benzene Quinones
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month
溶解性数据
In Vitro: 

Ethanol : 12.5 mg/mL(15.72 mM;Need ultrasonic and warming)

DMSO : 2 mg/mL(2.51 mM;ultrasonic and warming and heat to 80℃)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM1.2575 mL6.2875 mL12.5750 mL
5 mM0.2515 mL1.2575 mL2.5150 mL
10 mM0.1257 mL0.6287 mL1.2575 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。