Coenzyme Q9 (Ubiquinone Q9) 是啮齿类动物泛醌的主要形式，是电子传递链中的一种双亲分子组分，具有内源性抗氧化剂的作用。Coenzyme Q9 可减轻糖尿病引起的抗氧化防御机制的下降。Coenzyme Q9 改善左心室功能，减少心肌梗死面积和心肌细胞凋亡。
| 生物活性 | Coenzyme Q9 (Ubiquinone Q9), the major form of ubiquinone in rodents, is an amphipathic molecular component of the electron transport chain that functions as an endogenous antioxidant. Coenzyme Q9 attenuates the diabetes-induced decreases in antioxidant defense mechanisms. Coenzyme Q9 improves left ventricular performance and reduces myocardial infarct size and cardiomyocyteapoptosis[1][2]. |
| IC50& Target | Human Endogenous Metabolite |
|
体内研究
(In Vivo) | Coenzyme Q9 (5 mg/kg; p.o.; once a day for 4 weeks) reduces myocardial ischemia/reperfusion injury[2].
CoQ10and CoQ9are components of themitochondrial respiratory chain in mammals and can regulate some mitochondrial proteins/functions. Soybean, corn, and rapeseed oils are very rich sources of CoQ10, whereas CoQ9has been found in high concentrations in corn oil[3].
The lack of a functional CoQ9protein in homozygous CoQ9mutant (CoQ9(X/X)) mice causes a severe reduction in the CoQ7protein and a widespread CoQ deficiency and accumulation of demethoxyubiquinone. The deficit in CoQ induces a brain-specific impairment of mitochondrial bioenergetics performance, a reduction in respiratory control ratio, ATP levels and ATP/ADP ratio and specific loss of respiratory complex I. These effects lead to neuronal death and demyelinization with severe vacuolization and astrogliosis in the brain of CoQ9(X/X) mice that consequently die between 3 and 6 months of age[4].
| Animal Model: | Male Hartley guinea pigs of about 350-400 g body weight[2] | | Dosage: | 5 mg/kg of body weight | | Administration: | P.o.; once a day for 4 weeks | | Result: | Nutritional supplementation of CoQ9 can reduce myocardial ischemia/reperfusion injury to the same extent as CoQ10. |
|
| 分子量 | |
| 性状 | |
| Formula | |
| CAS 号 | |
| 中文名称 | |
| 结构分类 | |
| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | | Powder | -20°C | 3 years | | 4°C | 2 years | | In solvent | -80°C | 6 months | | -20°C | 1 month |
|
| 溶解性数据 | In Vitro: Ethanol : 12.5 mg/mL(15.72 mM;Need ultrasonic and warming) DMSO : 2 mg/mL(2.51 mM;ultrasonic and warming and heat to 80℃) 配制储备液 | 1 mM | 1.2575 mL | 6.2875 mL | 12.5750 mL | | 5 mM | 0.2515 mL | 1.2575 mL | 2.5150 mL | | 10 mM | 0.1257 mL | 0.6287 mL | 1.2575 mL |
*请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。 |
m.cnreagent.com