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Danshensu
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Danshensu图片
CAS NO:76822-21-4
包装与价格:
包装价格(元)
10 mM * 1 mL in Water电议
10mg电议
50mg电议
100mg电议
200mg电议
500mg电议

产品名称
丹参素
Dan shen suan A
Salvianic acid A
产品介绍
Danshensu 是丹参的有效成分,能够激活Nrf2信号通路,保护心血管。
生物活性

Danshensu, an active ingredient of Salvia miltiorrhiza, shows wide cardiovascular benefit by activatingNrf2signaling pathway.

体外研究
(In Vitro)

Danshensu (DSS) significantly decreases the level of the marker enzymes (creatine kinase and lactate dehydrogenase) from the coronary effluents and myocardial infarction size. This could markedly contribute to the recovery of cardiac function after I/R injury. DSS also has ROS scavenging activity and boosts endogenous antioxidants such as SOD, CAT, MDA, GSH-PX and HO-1 activities by activating nuclear factor erythroid-2-related factor 2 (Nrf2) signaling pathway which is mediated by Akt and ERK1/2 in western blot analysis[2].

体内研究
(In Vivo)

Acute treatment with a single dose of danshensu in rats with normal tHcy does not change plasma tHcy. In contrast, danshensu significantly lowers tHcy in rats with elevated tHcy. The relatively higher cysteine and glutathione levels after treatment with danshensu indicates that its tHcy-lowering effect is via increased activity of the trans-sulphuration pathway[1].

分子量

198.17

性状

Solid

Formula

C9H10O5

CAS 号

76822-21-4

中文名称

丹参素

结构分类
  • Phenylpropanoids
  • Simple Phenylpropanols
  • Phenols
  • Polyphenols
来源
  • Plants
  • Compositae
  • Hemistepta lyrata
  • Plants
  • Labiatae
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month
溶解性数据
In Vitro: 

H2O : 5 mg/mL(25.23 mM;Need ultrasonic)

DMSO : 1 mg/mL(5.05 mM;ultrasonic and warming and heat to 80℃)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM5.0462 mL25.2309 mL50.4617 mL
5 mM1.0092 mL5.0462 mL10.0923 mL
10 mM0.5046 mL2.5231 mL5.0462 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: PBS

    Solubility: 10 mg/mL (50.46 mM); Clear solution; Need ultrasonic and heat to 60℃

*以上所有助溶剂都可在本网站选购。