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Amubarvimab
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:2509447-07-6
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品名称
BRII-196
产品介绍
Amubarvimab (BRII-196) 是一种人 IgG1 mAb,可结合刺突蛋白受体结合域 (RBD) 上的非竞争表位,KD为 5.88 nM。Amubarvimab 可有效中和 SARS-CoV-2 变异体。
生物活性

Amubarvimab (BRII-196) is a humanIgG1mAb that bind to non-competing epitopes on thereceptor binding domain (RBD)ofspike protein, with aKDof 5.88 nM. Amubarvimab can effectively neutralize SARS-CoV-2 variants[1][2].

体外研究
(In Vitro)

Amubarvimab shows specific activity against wild-type SARS-CoV-2 and no cross-reactivity against other coronaviruses[1].
Amubarvimab binds to two regions spanning amino acids 453-505 in the receptor-binding motif (RBM) and amino acids residues 403-421 in the core region of RBD[1].

体内研究
(In Vivo)

Amubarvimab (10-50 mg/kg; i.p.) in combination with romlusevimab significantly decreases viral load in the lungs, and reduces lung pathology in a Syrian golden hamster model of SARS-CoV-2 infection[1].

CAS 号

2509447-07-6

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.