Nepuvibart

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Nepuvibart

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2640224-48-0

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

ZRC3308-B10

产品介绍

Nepuvibart (ZRC3308-B10) 是一种靶向SARS-CoV-2的单克隆抗体 (IgG1 型)。Nepuvibart 对SARS-CoV-2穗状蛋白的RBD上的非竞争性表位显示出良好的结合亲和力。Nepuvibart 可按 1:1 与 ZRC3308-A7 (HY-145642) 联合使用，对 COVID-19 的预防以及尚未发展为严重疾病的早期 COVID-19 有效。

生物活性

Nepuvibart (ZRC3308-B10) is ananti-SARS-CoV-2 monoclonal antibody(IgG1 type). Nepuvibart shows good binding affinity to a non-competing epitope on theRBDof theSARS-CoV-2spike protein. Nepuvibart can be used in combination withZRC3308-A7(HY-145642) at a ratio of 1:1, which is effective for the prevention of COVID-19 and the early stage of COVID-19 before the development of severe disease^[1].

IC₅₀& Target

SARS-CoV-2^[1].

体外研究
(In Vitro)

Nepuvibart (ZRC3308-B10; 0-5×10⁵ng/mL) shows virus neutralizing ability in VeroE6/Vero CCL81 (SARS-CoV-2 infection model) cells, when in combination with ZRC3308-A7 (ratio 1:1)^[1].
Nepuvibart neutralizes SARS-CoV-2 variants B.1.1.7, B.1.351, B.1.617.2, and B.1.617.2AY.1 in vitro, when in combination with ZRC3308-A7 (ratio 1:1)^[1].
Nepuvibart binds to the RBD of SARS-CoV-2 S1 protein^[1].

Cell Viability Assay^[1]

Cell Line:	VeroE6/Vero CCL81 cells (SARS-CoV-2 infection model)
Concentration:	0-5×10⁵ng/mL (in combination with ZRC3308-A7)
Incubation Time:	72 h
Result:	Showed potent neutralization activity with an IC₅₀of 0.1283 ng/mL.

体内研究
(In Vivo)

Nepuvibart (ZRC3308-B10; 0.5, 2.5, 25 mg/kg; 48 h prior to the SARS-CoV-2 infection) effectively prevents SARS-CoV-2 infection in syrian hamster, when in combination with ZRC3308-A7 (ratio 1:1)^[1].
Nepuvibart (0.5, 2.5, 25 mg/kg; i.p.; single) shows the serum levels remaines constant without much reduction for up to 7 days, in syrian hamster^[1].

Animal Model:	Female syrian hamster (7 to 10-week-old; SARS-CoV-2 infection model)^[1].
Dosage:	0.5, 2.5, 25 mg/kg
Administration:	Intraperitoneal injection; 48 h prior to the SARS-CoV-2 infection
Result:	Prevented SARS-CoV-2 infection when in combination with ZRC3308-A7.

CAS 号

2640224-48-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.