| CAS NO: | 2249888-53-5 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 生物活性 | Cevostamab (BFCR4350A; RG6160; RO7187797) is a humanized IgG1-based BsAb that targets membrane-proximal extracellular domain ofFcRH5on multiple myeloma (MM) cells as well asCD3on T cells. Moreover, Cevostamab facilitates efficient synapse formation, improves killing activity of T cells against MM tumor cells[1][2]. |
| IC50& Target | FcRH5; CD3[1][2] |
| 体外研究 (In Vitro) | Cevostamab shows a dose-dependent and robust killing of B cells and bone marrow plasma cells from peripheral blood mononuclear cell (PBMC)/BMMC samples from cynomolgus monkey[1]. |
| 体内研究 (In Vivo) | Cevostamab (0.5 mg/kg; i.v.; once weekly for ) suppresses the growth of established MOLP-2 tumors in mice reconstituted with human immune cells[1]. |
| CAS 号 | 2249888-53-5 |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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