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Peldesine dihydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Peldesine dihydrochloride图片
CAS NO:2772702-10-8
包装与价格:
包装价格(元)
10 mM * 1 mL in DMSO电议
5mg电议
10mg电议
50mg电议
100mg电议

产品名称
BCX 34 dihydrochloride
产品介绍
Peldesine (BCX 34) dihydrochloride 是一种有效的,竞争性,可逆和口服活性的嘌呤核苷磷酸化酶 (PNP) 抑制剂,对人,大鼠和小鼠红细胞 (RBC)PNPIC50分别为 36 nM,5 nM 和 32 nM。Peldesine dihydrochloride 还是一种 T 细胞 (T-cell) 增殖抑制剂,IC50为 800 nM。Peldesine dihydrochloride 可用于皮肤 T 细胞淋巴瘤,牛皮癣和HIV感染的研究。
生物活性

Peldesine (BCX 34) dihydrochloride is a potent, competitive, reversible and orally activepurine nucleoside phosphorylase (PNP)inhibitor withIC50s of 36 nM, 5 nM, and 32 nM forhuman, rat, and mouse red blood cell (RBC) PNP, respectively. Peldesine dihydrochloride is also aT-cellproliferation inhibitor with anIC50of 800 nM. Peldesine dihydrochloride has the potential for cutaneous T-cell lymphoma, psoriasis andHIVinfectionresearch[1][2][3][4].

IC50& Target

IC50: 36 nM (Human RBC PNP), 5 nM (Rat RBC PNP), 32 nM (Mouse RBC PNP), and 800 nM (Human T-cell proliferation)[3]
Ki: 23 nM (Human RBC PNP)[3]
HIV[4]

体外研究
(In Vitro)

Peldesine (BCX 34; 0-50 μM; 72 hours; Jurkat cells) could inhibit the T-cell proliferation completely at a concentration of less than 10 μM, in the presence of dGuo (10 μM). In contrast, the B-cell proliferation is not affected by Peldesine[1].
Peldesine (BCX 34) suppresses T-cell immune reaction in an IL-2-independent manner, and this means that Peldesine might affect a late phase rather than an early stage in T-cell activation[1].
Peldesine also, in the presence but not in the absence of deoxyguanosine, inhibits human leukemia CCRF-CEM T-cell proliferation with an IC50of 0.57 μM but not rat or mouse T-cell proliferation up to 30 μM[3].

Cell Viability Assay[1]

Cell Line:Jurkat cells
Concentration:0-50 μM
Incubation Time:72 hours
Result:In the presence of 10 μM dCuo, had a complete inhibitory effect for T-cell lines.
Clinical Trial
分子量

314.17

性状

Solid

Formula

C12H13Cl2N5O

CAS 号

2772702-10-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

DMSO : 200 mg/mL(636.60 mM;Need ultrasonic)

H2O : 33.33 mg/mL(106.09 mM;Need ultrasonic)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM3.1830 mL15.9150 mL31.8299 mL
5 mM0.6366 mL3.1830 mL6.3660 mL
10 mM0.3183 mL1.5915 mL3.1830 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。