CAS NO: | 2772702-10-8 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | Peldesine (BCX 34) dihydrochloride is a potent, competitive, reversible and orally activepurine nucleoside phosphorylase (PNP)inhibitor withIC50s of 36 nM, 5 nM, and 32 nM forhuman, rat, and mouse red blood cell (RBC) PNP, respectively. Peldesine dihydrochloride is also aT-cellproliferation inhibitor with anIC50of 800 nM. Peldesine dihydrochloride has the potential for cutaneous T-cell lymphoma, psoriasis andHIVinfectionresearch[1][2][3][4]. | ||||||||||||||||
IC50& Target | IC50: 36 nM (Human RBC PNP), 5 nM (Rat RBC PNP), 32 nM (Mouse RBC PNP), and 800 nM (Human T-cell proliferation)[3] | ||||||||||||||||
体外研究 (In Vitro) | Peldesine (BCX 34; 0-50 μM; 72 hours; Jurkat cells) could inhibit the T-cell proliferation completely at a concentration of less than 10 μM, in the presence of dGuo (10 μM). In contrast, the B-cell proliferation is not affected by Peldesine[1]. Cell Viability Assay[1]
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Clinical Trial | |||||||||||||||||
分子量 | 314.17 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C12H13Cl2N5O | ||||||||||||||||
CAS 号 | 2772702-10-8 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) | ||||||||||||||||
溶解性数据 | In Vitro: DMSO : 200 mg/mL(636.60 mM;Need ultrasonic) H2O : 33.33 mg/mL(106.09 mM;Need ultrasonic) 配制储备液
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