JTT 551

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JTT 551

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

776309-04-7

包装与价格：

包装	价格(元)
10 mM * 1 mL in DMSO	电议
5mg	电议
10mg	电议
50mg	电议
100mg	电议

产品介绍

JTT 551 是一种选择性的蛋白酪氨酸磷酸酶 1B (PTP1B) 抑制剂，K_i值为 0.22 μM，同时对 T 细胞蛋白酪氨酸磷酸酶 (TCPTP）也有作用，K_i值为 9.3 μM，可用于二型糖尿病的研究。

生物活性

JTT 551 is selective a protein tyrosinephosphatase1B (PTP1B) inhibitor, withK_is of 0.22 μM and 9.3 μM for PTP1B and TCPTP (T-cell protein tyrosine phosphatase), respectively; JTT 551 can be used in the research of type 2 diabetes mellitus.

IC₅₀& Target

IC50: 0.22 μM (PTP1B), 9.3 μM (TCPTP)^[1]

体外研究
(In Vitro)

JTT 551 is selective a protein tyrosine phosphatase 1B (PTP1B) inhibitor, with K_is of 0.22 μM and 9.3 μM for PTP1B and TCPTP (T-cell protein tyrosine phosphatase), respectively. JTT 551 shows low affinity at CD45 PTP (CD45) and leucocyte common antigen-related (LAR) PTP with K_is of both >30 μM. Furthermore, JTT-551 (10 and 30 μM) enhances the insulin-induced deoxyglucose uptake in a dosedependent manner^[1].

体内研究
(In Vivo)

JTT 551 (3 mg/kg, 30 mg/kg, p.o.) dose-dependently decreases blood glucose level on Days 7, 14 and 28 in db/db Mice. JTT 551 also significantly reduces triglyceride (TG) level at 30 mg/kg on Day 7 but does not alter insulin and total cholesterol (TC) levels^[1].

分子量

605.85

性状

Solid

Formula

C₃₄H₄₃N₃O₃S₂

CAS 号

776309-04-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据

In Vitro:

DMSO : 100 mg/mL(165.06 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	1.6506 mL	8.2529 mL	16.5057 mL
5 mM	0.3301 mL	1.6506 mL	3.3011 mL
10 mM	0.1651 mL	0.8253 mL	1.6506 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture and light)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。