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TPP-1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:2426685-25-6
包装与价格:
包装价格(元)
25mg电议
50mg电议
100mg电议

产品介绍
TPP-1 是PD-1/PD-L1相互作用的有效抑制剂。TPP-1 与 PD-L1 特异性高亲和力结合 (KD=95 nM)。动物模型中,TPP-1 通过再激活 T 细胞功能抑制肿瘤生长。
生物活性

TPP-1 is a potent inhibitor of the PD-1/PD-L1interaction. TPP-1 binds specifically toPD-L1with a high affinity (KD=95 nM). TPP-1 inhibits human tumor growthin vivovia reactivating T-cell function[1].

体外研究
(In Vitro)

TPP-1 binds to PD-L1 with high affinity and blocks PD-1/PD-L1 interaction. The KD value of PD-L1 with TPP-1 peptide is about 95 nmol/L (around five times less than that with PD-1), The binding site of TPP-1 to PD-L1 is close to the interactive site of PD-1 and PD-L1[1].
TPP-1 (4 μM) reactivates T-cell functions, it induces IFNγ release significantly higher than control and SPP-1, and the TPP-1 group shows similar outcomes for cell proliferation[1].

体内研究
(In Vivo)

TPP-1 (subcutaneous injection; 4 mg/kg; every other day eight times; 32 days) inhibits tumor growth (compared with SPP-1 and control). The growth rate in TPP-1-treated mice is 56%. And when administered in the absence of T cells (control group), TPP-1 has no effect on the growth of the H460-luc tumors[1].

Animal Model:5 to 6-week-old female Balb/c nude mice injected with H460 cells transfected with the plvx-puro/luciferase lentiviral vector[1]
Dosage:4 mg/kg
Administration:Subcutaneous injection; 4 mg/kg; every other day eight times; 32days
Result:Inhibited the tumor growth in a tumor xenograft model via reactivating T-cell function.
分子量

2488.67

性状

Solid

Formula

C107H150N34O32S2

CAS 号

2426685-25-6

Sequence Shortening

SGQYASYHCWCWRDPGRSGGSK

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder-80°C2 years
-20°C1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

H2O : 50 mg/mL(20.09 mM;Need ultrasonic)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM0.4018 mL2.0091 mL4.0182 mL
5 mM0.0804 mL0.4018 mL0.8036 mL
10 mM0.0402 mL0.2009 mL0.4018 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。