CAS NO: | 2426685-25-6 |
包装 | 价格(元) |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | TPP-1 is a potent inhibitor of the PD-1/PD-L1interaction. TPP-1 binds specifically toPD-L1with a high affinity (KD=95 nM). TPP-1 inhibits human tumor growthin vivovia reactivating T-cell function[1]. | ||||||||||||||||
体外研究 (In Vitro) | TPP-1 binds to PD-L1 with high affinity and blocks PD-1/PD-L1 interaction. The KD value of PD-L1 with TPP-1 peptide is about 95 nmol/L (around five times less than that with PD-1), The binding site of TPP-1 to PD-L1 is close to the interactive site of PD-1 and PD-L1[1].TPP-1 (4 μM) reactivates T-cell functions, it induces IFNγ release significantly higher than control and SPP-1, and the TPP-1 group shows similar outcomes for cell proliferation[1]. | ||||||||||||||||
体内研究 (In Vivo) | TPP-1 (subcutaneous injection; 4 mg/kg; every other day eight times; 32 days) inhibits tumor growth (compared with SPP-1 and control). The growth rate in TPP-1-treated mice is 56%. And when administered in the absence of T cells (control group), TPP-1 has no effect on the growth of the H460-luc tumors[1].
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分子量 | 2488.67 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C107H150N34O32S2 | ||||||||||||||||
CAS 号 | 2426685-25-6 | ||||||||||||||||
Sequence Shortening | SGQYASYHCWCWRDPGRSGGSK | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) | ||||||||||||||||
溶解性数据 | In Vitro: H2O : 50 mg/mL(20.09 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |