包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | TPP-1 TFA is a potent inhibitor of the PD-1/PD-L1interaction. TPP-1 TFA binds specifically toPD-L1with a high affinity (KD=95 nM). TPP-1 TFA inhibits human tumor growthin vivovia reactivating T-cell function[1]. | ||||||||
体外研究 (In Vitro) | TPP-1 TFA binds to PD-L1 with high affinity and blocks PD-1/PD-L1 interaction. The KD value of PD-L1 with TPP-1 TFA peptide is about 95 nmol/L (around five times less than that with PD-1), The binding site of TPP-1 TFA to PD-L1 is close to the interactive site of PD-1 and PD-L1[1].TPP-1 TFA (4 μM) reactivates T-cell functions, it induces IFNγ release significantly higher than control and SPP-1, and the TPP-1 TFA group shows similar outcomes for cell proliferation[1]. | ||||||||
体内研究 (In Vivo) | TPP-1 TFA (subcutaneous injection; 4 mg/kg; every other day eight times; 32 days) inhibits tumor growth (compared with SPP-1 and control). The growth rate in TPP-1 TFA-treated mice is 56%. And when administered in the absence of T cells (control group), TPP-1 TFA has no effect on the growth of the H460-luc tumors[1].
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分子量 | 2602.69 | ||||||||
Formula | C109H151F3N34O34S2 | ||||||||
Sequence Shortening | SGQYASYHCWCWRDPGRSGGSK | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |