CAS NO: | 869748-10-7 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | A-770041 is a selective and orally active Src-familyLckinhibitor. A-770041 inhibits Lck with anIC50value of 147 nM with the presence of 1 mM ATP. A-770041 shows 300-fold selective to Lck over Fyn, the otherSrcfamily kinase involved in T-cell signaling. A-770041 can be used for the research of acute rejection[1][2]. | ||||||||||||||||
IC50& Target | IC50: 0.147 μM (Lck), 9.1 μM (Src), 14.1 μM (Fgr), 44.1 μM (Fyn)[1] | ||||||||||||||||
体外研究 (In Vitro) | A-770041 selective inhibits Lck with an IC50value of 0.147 μM, and inhibits other Src family kinase Src, Fgr, Fyn with IC50s of 9.1, 14.1 and 44.1 μM, respectively[1].A-770041 (0-30 μM; 2 h) dose-dependently inhibits anti-CD3 induced IL-2 production with an EC50value of 80 nM[1]. | ||||||||||||||||
体内研究 (In Vivo) | A-770041 (2.5 mg/kg; i.g. once) inhibits concanavalin A-induced IL-2 in vivo[1].A-770041 (2.5-20 mg/kg/day; for 14 days) dose-dependently increases the survival rate with doses of 5 and 10 mg/kg/day, and survives 100% of transplanted grafts until 14 days with doses of 10 and 20 mg/kg/day[1].
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分子量 | 621.73 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C34H39N9O3 | ||||||||||||||||
CAS 号 | 869748-10-7 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : ≥ 100 mg/mL(160.84 mM) *"≥" means soluble, but saturation unknown. 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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