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3-Hydroxykynurenine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
3-Hydroxykynurenine图片
CAS NO:484-78-6
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品名称
3-hydroxy-DL-Kynurenine
产品介绍
3-Hydroxykynurenine 是一种色氨酸代谢物,是潜在的内源性神经毒素,在几种神经退行性疾病中表达水平都有升高的现象。3-Hydroxykynurenine 诱导神经细胞凋亡 (apoptosis)。
生物活性

3-Hydroxykynurenine, a metabolite of tryptophan, is a potential endogenous neurotoxin whose increased levels have been described in several neurodegenerative disorders. 3-Hydroxykynurenine induces neuronalapoptosis[1].

IC50& Target

Human Endogenous Metabolite

 

体外研究
(In Vitro)

3-Hydroxykynurenine-induced neuronal cell death shows several features of apoptosis[1].
3-Hydroxykynurenine is a metabolic intermediate of the kynurenine pathway, the major metabolic pathway of tryptophan (Trp)[1].
3-Hydroxykynurenine acts as an endogenous neurotoxin in the brain under pathological conditions[1].
3-Hydroxykynurenine (20-100 μM) significantly inhibits CD4+ T-cell proliferation in a dose-dependent manner with IC50 of approximately 70 μM[2].
3-Hydroxykynurenine (20-100 μM) induces significant CD4+ T-cell-mediated cell death in a dose-dependent manner[2].

Cell Proliferation Assay[2]

Cell Line:CD3/CD28 bead-stimulated CD4+ T cells
Concentration:0, 20, 40, 60, 80, and 100 μM
Incubation Time:72 hours
Result:Significantly inhibited CD4+ T-cell proliferation in a dose-dependent manner with an IC50 of approximately 70 μM.
体内研究
(In Vivo)

3-Hydroxykynurenine administration (560 mg/kg IP on a daily basis on days 1 to 7, days 7 to 14, or days 1 to 14) results in significant prolongation of graft survival whether administered between days 1 to 7, days 7 to 14, or days 1 to 14[2].

Animal Model:BALB/c (H2d) mice[2]
Dosage:560 mg/kg
Administration:IP injection
Result:There was significant prolongation of graft survival in all treatment groups in comparison to the controls.
分子量

224.21

性状

Solid

Formula

C10H12N2O4

CAS 号

484-78-6

中文名称

3-羟基犬尿氨酸

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month
溶解性数据
In Vitro: 

1M HCl : 33.33 mg/mL(148.66 mM;ultrasonic and adjust pH to 1 with HCl)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM4.4601 mL22.3005 mL44.6010 mL
5 mM0.8920 mL4.4601 mL8.9202 mL
10 mM0.4460 mL2.2301 mL4.4601 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。