CAS NO: | 159646-83-0 |
包装 | 价格(元) |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | QL9 (QLSPFPFDL) is a high-affinity alloantigen for the 2C T cell receptor (TCR). | ||||||||||||||||
IC50& Target | TCR[1] | ||||||||||||||||
体外研究 (In Vitro) | Mouse T cell clone 2C recognizes two different major histocompatibility (MHC) ligands, the self MHC Kband the allogeneic MHC Ld. Two distinct peptides, SIY (SIYRYYGL) and QL9 (QLSPFPFDL), act as strong and specific agonists when bind to Kband Ld, respectively. QL9 binding to MHC Ldis influenced by the majority of peptide side chains, distributed across the entire length of the peptide. Findings with both systems, but QL9-Ldin particular, suggest that many single-residue substitutions, introduced into peptides to improve their binding to MHC and thus their vaccine potential, could impair T cell reactivity due to their dual impact on TCR binding. T cell activation assays are performed to measure effects of peptide SIY and QL9 residues on T cell function[2]. | ||||||||||||||||
分子量 | 1063.21 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C52H74N10O14 | ||||||||||||||||
CAS 号 | 159646-83-0 | ||||||||||||||||
Sequence | Gln-Leu-Ser-Pro-Phe-Pro-Phe-Asp-Leu | ||||||||||||||||
Sequence Shortening | QLSPFPFDL | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) | ||||||||||||||||
溶解性数据 | In Vitro: H2O : 33.33 mg/mL(31.35 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |