您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > QL9
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
QL9
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:159646-83-0
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
QL9 是针对2C T细胞受体 (TCR) 的高亲和力同种异体抗原。
生物活性

QL9 (QLSPFPFDL) is a high-affinity alloantigen for the 2C T cell receptor (TCR).

IC50& Target

TCR[1]

体外研究
(In Vitro)

Mouse T cell clone 2C recognizes two different major histocompatibility (MHC) ligands, the self MHC Kband the allogeneic MHC Ld. Two distinct peptides, SIY (SIYRYYGL) and QL9 (QLSPFPFDL), act as strong and specific agonists when bind to Kband Ld, respectively. QL9 binding to MHC Ldis influenced by the majority of peptide side chains, distributed across the entire length of the peptide. Findings with both systems, but QL9-Ldin particular, suggest that many single-residue substitutions, introduced into peptides to improve their binding to MHC and thus their vaccine potential, could impair T cell reactivity due to their dual impact on TCR binding. T cell activation assays are performed to measure effects of peptide SIY and QL9 residues on T cell function[2].

分子量

1063.21

性状

Solid

Formula

C52H74N10O14

CAS 号

159646-83-0

Sequence

Gln-Leu-Ser-Pro-Phe-Pro-Phe-Asp-Leu

Sequence Shortening

QLSPFPFDL

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder-80°C2 years
-20°C1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

H2O : 33.33 mg/mL(31.35 mM;Need ultrasonic)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM0.9405 mL4.7027 mL9.4055 mL
5 mM0.1881 mL0.9405 mL1.8811 mL
10 mM0.0941 mL0.4703 mL0.9405 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。