DiaPep277

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DiaPep277

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

179822-83-4

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

DiaPep277 是一中含有 24 个氨基酸的多肽，起源于 HSP60 的 437-460 位点。DiaPep277 可抑制 NOD 小鼠 β-细胞破坏的进展。DiaPep277 在糖尿病动物模型中对糖尿病源性 T 细胞具有免疫调节作用。

生物活性

DiaPep277 is a 24 amino acid peptide derived from positions 437-460 in HSP60. DiaPep277 arrests the progression of β-cell destruction in NOD mice. DiaPep277 has an immune modulatory effect on diabetogenic T cells in animal models of diabetes^[1]^[2].

体内研究
(In Vivo)

DiaPep277 (50 μg; i.p.; single dosage) causes strong splenic T cells responses, and strong diabetogenic clones 27, C7, and C9 responses^[2].

Animal Model:	Female NOD mice (diabetes model)^[2]
Dosage:	50 μg
Administration:	i.p.; single dosage
Result:	Caused strong splenic T cells responses, and strong diabetogenic clones 27, C7, and C9 responses.

Clinical Trial

分子量

2390.73

Formula

C₁₀₆H₁₈₀N₂₈O₃₄

CAS 号

179822-83-4

Sequence Shortening

VLGGGVALLRVIPALDSLTPANED

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

H₂O

Peptide Solubility and Storage Guidelines:

1. Calculate the length of the peptide.

2. Calculate the overall charge of the entire peptide according to the following table:

	Contents	Assign value
Acidic amino acid	Asp (D), Glu (E), and the C-terminal -COOH.	-1
Basic amino acid	Arg (R), Lys (K), His (H), and the N-terminal -NH₂	+1
Neutral amino acid	Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)	0

3. Recommended solution:

Overall charge of peptide	Details
Negative (<0)	1. Try to dissolve the peptide in water first. 2. If water fails, add NH₄OH (<50 μL). 3. If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0)	1. Try to dissolve the peptide in water first. 2. If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3. If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)	1. Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2. For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.