CAS NO: | 1116433-11-4 |
包装 | 价格(元) |
1mg | 电议 |
5mg | 电议 |
生物活性 | Itolizumab (Anti-HumanCD6Recombinant Antibody) is a humanized recombinantanti-CD6monoclonal antibody (MAb) targeting the extracellular SRCR distal domain 1 ofCD6. Itolizumab reduces T-cell proliferation and inhibits the production of pro-inflammatory cytokines, such as INF-γ, TNFα andIL-6. Itolizumab can be used in the research of psoriasis, rheumatoid arthritis (RA), COVID-19[1][2][3]. | ||||||||
IC50& Target | CD6[1] | ||||||||
体外研究 (In Vitro) | Itolizumab (100 μg/mL) inhibits T cell proliferation[4]. | ||||||||
体内研究 (In Vivo) | Itolizumab (60 μg or 300μg, i.p., everyday) shows therapeutic efficiency in a humanized xenograft mouse model of Graft Vs Host Disease (GVHD)[7].
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CAS 号 | 1116433-11-4 | ||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |