Goserelin (ICI 118630) 是一种促性腺激素释放激素 (GnRH/LHRH) 十肽类似物，能作为GnRH激动剂。Goserelin 可用于乳腺癌、上皮性卵巢癌和前列腺癌的研究。
| 生物活性 | Goserelin (ICI 118630), a decapeptide analogue of gonadotropin-releasing hormone (GnRH/LHRH), functions as aGnRHagonist. Goserelin can be used for the research of breastcancer, epithelial ovariancancerand prostatecancer[1][2]. |
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体外研究
(In Vitro) | Goserelin (1 nM-1 mM; 48-72 hours) promots EOC cell apoptosis[1].
Goserelin (100 μM; 24-72 hours) regulates the expression of human apoptosis-related genes in SKOV3-ip cells[1].
Goserelin (100 μM; 24-72 hours) influences EOC cell apoptosis by upregulating FOXO1 through the PI3K/AKT signaling pathway[1].
Apoptosis Analysis[1] | Cell Line: | SKOV3 cells, SKOV3-ip cells, A2780 cells (human EOC cell lines) | | Concentration: | 1 nM, 10 nM, 100 nM, 1 μM, 10 μM, 100 μM, 1 mM | | Incubation Time: | 48 hours, 72 hours | | Result: | Significantly increased the total apoptosis rate of SKOV3-ip, SKOV3 and A2780 cells. |
Western Blot Analysis[1] | Cell Line: | SKOV3 cells, SKOV3-ip cells, A2780 cells (human EOC cell lines) | | Concentration: | 1 nM, 10 nM, 100 nM, 1μM , 10 μM, 100 μM, 1 mM | | Incubation Time: | 48 hours, 72 hours | | Result: | The expression of cleaved-caspase-3 and cleaved-PARP were observably increased at 100 μM. |
RT-PCR[1] | Cell Line: | SKOV3-ip cells | | Concentration: | 100 μM | | Incubation Time: | 24 hours, 48 hours, 72 hours | | Result: | Expression of human apoptosis-related genes regulated |
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体内研究
(In Vivo) | Goserelin (100 μg; s.c.; daily; for 19 days) significantly increases the proportion of apoptotic cells in the subcutaneous xenograft tumors[1].
| Animal Model: | Five-week-old specific-pathogen free (SPF) female nude mice (18-20 g), subcutaneous xenograft tumor model[1] | | Dosage: | 100 μg/mice | | Administration: | Subcutaneous injection, daily, for 19 days | | Result: | Significantly increased the proportion of apoptotic cells in the subcutaneous xenograft tumors |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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