| CAS NO: | 348622-88-8 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| Cas No. | 348622-88-8 |
| 别名 | UK383367, UK-383367 |
| 化学名 | 5-[(3R)-6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl]-1,2,4-oxadiazole-3-carboxamide |
| Canonical SMILES | C1CCC(CC1)CCCC(CC(=O)NO)C2=NC(=NO2)C(=O)N |
| 分子式 | C15H24N4O4 |
| 分子量 | 324.38 |
| 溶解度 | DMF: 16 mg/mL,DMSO: 25 mg/mL,DMSO:PBS (pH 7.2)(1:5): 0.16 mg/mL,Ethanol: 16 mg/mL |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | UK 383367 is a novel procollagen C-protein (PCP) inhibitor being investigated for the treatment of post-surgical dermal scarring, which potently inhibits the activity of PCP with the value of 50% inhibition concentration IC50of 44 nM, as well as a selective inhibitor of matrix metalloproteinases (MMPs) with values of IC50>60,000 nM for MMP-2 and >10,000 nM for MMP-1, MMP-3, MMP-9 and MMP-4. Although the mechanism is not clear yet, UK 383367 also exhibits weak inhibitory effects against phosphodiesterase-4 (PDE-4) enzyme, including PDE-4a, PDE-4b, PDE-4c and PDE-4d, with values of IC50of 1.8 μM, 1.5 μM, 2.4 μM and 0.9 μM respectively. Reference [1].G. A. Allan, J. I. Gedge, A. N. R. Nedderman, S. J. Roffey, H. F. Small and R. Webster. Pharmacokinetics and metabolism of UK-383,367 in rats and dogs: a rationale for long-lived plasma radioactivity. Xenobiotica 2006; 36(5): 399-418 |
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