QA-68 (QA-68-ZU81) 是一种有效的BRD9降解剂。QA-68 能抑制细胞周期进程和细胞集落形成。QA-68 对急性髓系白血病 (AML) 细胞系具有抗增殖活性。
| 生物活性 | QA-68 (QA-68-ZU81) is a potentbromodomain-containing protein 9 (BRD9)degrader. QA-68 can inhibit cell cycle progression and cell colony formation. QA-68 has antiproliferative activity against acute myeloid leukemia (AML) cell lines[1]. |
| IC50& Target[1] | |
体外研究
(In Vitro) | QA-68 (0-1000 nM; 24 h) exhibits antiproliferative activity against MV4-11, SKM-1 and Kasumi-1-luc+ cells, and inhibits BRD9 protein expression in MV4-11, SKM-1, SEM, NALM6, RS4;11[1].
QA-68 (0.1-1000 nM; 4 days) effectively inhibits SKM-1 cell cycle progression[1].
QA-68 (1000 nM; 12 days) inhibits colony formation of additional primary AML bone marrow and PBMC cells[1].
Cell Proliferation Assay[1] | Cell Line: | MV4-11, SKM-1 and Kasumi-1-luc+ cells | | Concentration: | 0-1000 nM | | Incubation Time: | 24 h | | Result: | Exhibited concentration-dependent inhibition of proliferation of MV4-11, SKM-1 and Kasumi-1-luc+ cells with IC50s of 1-10 nM in MV4;11 and SKM-1, and IC50 of 10-100 nM in Kasumi-1-luc +, respectively. |
Cell Cycle Analysis[1] | Cell Line: | SKM-1cells | | Concentration: | 0.1, 1, 10, 100 and 1000 nM | | Incubation Time: | 6 days | | Result: | Effectively inhibited SKM-1 cell cycle progression. |
Western Blot Analysis[1] | Cell Line: | MV4-11, SKM-1, SEM, NALM6, RS4;11 | | Concentration: | 0, 1, 10, 100 and 1000 nM | | Incubation Time: | 24 h | | Result: | Inhibited BRD9 protein in all tested cell lines. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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