LSD1-IN-13 hydrochloride

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CAS NO:

2170347-90-5

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

LSD1-IN-13 hydrochloride (compound 7e) 是一种口服有效的LSD1抑制剂，其IC₅₀值为 24.43 nM。LSD1-IN-13 hydrochloride 可激活 CD86 表达，其EC₅₀值为 470 nM。LSD1-IN-13 hydrochloride 诱导 AML (急性髓系白血病)细胞系分化。

生物活性	LSD1-IN-13 hydrochloride (compound 7e) is an orally active and potentLSD1inhibitor, with anIC₅₀of 24.43 nM. LSD1-IN-13 hydrochloride can activate CD86 expression, with anEC₅₀of 470 nM. LSD1-IN-13 hydrochloride induces differentiation of AML (acute myeloid leukemia) cell lines^[1].
IC₅₀& Target	IC₅₀: 24.43 ± 1.08 nM (LSD1), 5.00 ± 0.28 μM (LSD2), >100 μM (MAO-A), >100 μM (MAO-B)^[1]
体外研究 (In Vitro)	LSD1-IN-13 hydrochloride (compound 7e) shows good selectivity over LSD2 (205-fold) and MAOs (>4000-fold)^[1]. LSD1-IN-13 hydrochloride shows potent and selective antiproliferative activity in MV-4-11, with an IC₅₀of 1.36 μM^[1].
体内研究 (In Vivo)	LSD1-IN-13 hydrochloride (compound 7e) (MV-4-11 xenograft mice, 0-20 mg/kg, Orally, daily for 15 days) suppresses tumor growth significantly in a dose-dependent manner^[1].
分子量	448.02
Formula	C₂₃H₃₀ClN₃O₂S
CAS 号	2170347-90-5
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.