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DVR-01
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
DVR-01图片
CAS NO:330461-34-2
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
DVR-01 是HBV的抑制剂,在 AML12HBV10 和 HepDES19 细胞中的EC50值分别为 1.7 和 1.6 μM。DVR-01 对 HBV 突变体具有抑制活性,EC50为 2.403-3.273 μM。DVR-01 可用于 HBV 感染以及相关疾病的研究。
生物活性

DVR-01 is aHBVinhibitor withEC50values of 1.7 and 1.6 μM in AML12HBV10 and HepDES19 cells, respectively. DVR-01 shows antiviral activity against drug-resistantHBVmutants withEC50s of 2.403-3.273 μM. DVR-01 can be used for the research of HBVinfectionand related diseases[1].

体外研究
(In Vitro)

DVR-01 (0-10 μM; 4 d) inhibits HBV in human hepatoma cells with EC50values of 1.7 and 1.6 μM in AML12HBV10 and HepDES19 cells, respectively[1].
DVR-01 (0.156-10 μM; 2 d) selectively disrupts the pgRNA encapsidation by HBV[1].
DVR-01 (3 d) shows antiviral activity against hepadnaviruses in human hepatoma cells with EC50s of 2.899, >10 and >25 μM for HBV, WHV and DHBV, respectively[1].
DVR-01 (0.0097-10 μM; 2 d) shows antiviral activity against drug-resistant HBV mutants with EC50s of 2.899, 3.273, 3.180, 2.752, 2.567 and 2.403 μM for wt, rtL180 M/rtM204V, rtA181V, rtN236T, rtM204I and rtL180 M/rtM204V/rtT184G/rtS202I, respectively[1].

分子量

406.93

Formula

C20H23ClN2O3S

CAS 号

330461-34-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.