Avrainvillamide ((+)-Avrainvillamide) is a naturally occurring alkaloid with antiproliferative effects, binds to the nuclear chaperone nucleophosmin, a proposed oncogenic protein that is overexpressed in many different human tumors. Avrainvillamide affectscell biologyboth by directly binding NPM1 andCrm1as well as by inhibiting the association of these proteins with certain native cellular partners. Avrainvillamide, anantibiotic, inhibits growth of multi-drug resistantStaphylococcus aureus,Streptococcus pyogenes, andEnterococcus faecalis, with MICs of 12.5, 12.5 and 25 μg/ml, respectively^[1][2][3].

Avrainvillamide ((+)-Avrainvillamide) restores nucleolar localization of certain acute myeloid leukemia (AML)-associated mutant forms of NPM1 and provide evidence that this relocalization is mediated by interactions of Avrainvillamide with mutant NPM1 and exportin-1 (Crm1)^[2].
Avrainvillamide ((+)-Avrainvillamide) shows antiproliferative activities in T-47D (breast cancer) cells and LNCaP (prostate cancer) cells with GI₅₀s of 0.33 and 0.42 μM, respectively^[2].

445.51

C₂₆H₂₇N₃O₄

269741-97-1

• Alkaloids
• Pyrrole Alkaloids

• Alkaloids
• Indole Alkaloids

Aspergillus sp

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.