CAS NO: | 505-44-2 |
包装: | 1mg (61.25 mM * 100 μL in Ethanol) |
市场价: | 800元 |
生物活性 | Iberin (NSC 321801), a sulfoxide analogue of sulforaphane, is a naturally occurring member of isothiocyanate family. Iberin inhibits cell survival with anIC50of 2.3 μM in HL60 cell. Iberin inducesapoptosis. | |
IC50& Target |
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体外研究 (In Vitro) | Iberin inhibits the growth of neuroblastoma cells in a dose- and time-dependent manner. The iberin-induced cell cycle arrest in neuroblastoma cells is associated with inhibition of expression of cyclin-dependent kinase Cdk2, Cdk4, and Cdk6 proteins. There is an increase in apoptotic cell death in iberin treated cells as compared with control cells. The iberin-induced apoptosis is found to be associated with activation of caspase-9, caspase-3, and PARP[2]. Iberin inhibits growth of human glioblastoma cells in cell proliferation assays, enhances cytotoxicity, and induces apoptosis by activation of caspase-3 and caspase-9[3]. | |
体内研究 (In Vivo) | Iberin is tested in anin vivoforeign-body infection mouse model, and the results show no significantly difference in bacterial clearance between treated and nontreated miced[4]. Iberin increases tissue levels of the phase II detoxification enzymes quinone reductase and glutathione S-transferase in a variety of rat tissues[5]. | |
分子量 | 163.26 | |
性状 | Liquid | |
Formula | C5H9NOS2 | |
CAS 号 | 505-44-2 | |
结构分类 |
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来源 |
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运输条件 | Room temperature in continental US; may vary elsewhere. | |
储存方式 | Solution, -20°C, 2 years | |
溶解性数据 | In Vitro: DMSO : ≥ 310 mg/mL(1898.81 mM) Ethanol : 10 mg/mL(61.25 mM;Need ultrasonic) *"≥" means soluble, but saturation unknown. In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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