4-iodo-SAHA

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4-iodo-SAHA

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1219807-87-0

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

ISAHA

产品介绍

4-Iodo-SAHA (1k) 是一种 I 类和 II 类histone deacetylase (HDAC)的抑制剂，对 Skbr3、HT29、U937、JA16 和 HL60 细胞的EC₅₀值分别为 1.1、0.95、0.12、0.24、0.85 和 1.3 μM。4-Iodo-SAHA 可用于癌症的研究。

生物活性

4-Iodo-SAHA (1k) is an orally active class I and class IIhistone deacetylase (HDAC)inhibitor withEC₅₀s of 1.1, 0.95, 0.12, 0.24, 0.85 and 1.3 μM for Skbr3, HT29, U937, JA16 and HL60 cell lines, respectively. 4-Iodo-SAHA (1k) can be used for the research ofcancer^[1].

体外研究
(In Vitro)

4-Iodo-SAHA (0.1-100 μM; 48 h) inhibits Skbr3, HT29, U937, JA16 and HL60 cell lines^[1].
4-Iodo-SAHA (2 μM; 6-24 h) affects acetylated H4 and p21 levels in SKBR3 cells^[1].

Cell Proliferation Assay^[1]

Cell Line:	SKBR3, HT29, U937, JA16 and HL60 cell lines
Concentration:	0.1-100 μM
Incubation Time:	48 h
Result:	Inhibited SKBR3, HT29, U937, JA16 and HL60 cell lines withEC₅₀s of 1.1, 0.95, 0.12, 0.24, 0.85 and 1.3 μM , respectively. Showed 10-fold potent as an inhibitor of U937 cell line compared to SAHA.

Western Blot Analysis^[1]

Cell Line:	SKBR3-breast-derived cell line
Concentration:	2 μM
Incubation Time:	6, 12 and 24 h
Result:	Time-dependently up regulated histone H4 acetylation and p21/WAF1 cell cycle inhibitor accumulation in SKBR3 cells.

体内研究
(In Vivo)

4-Iodo-SAHA (1k) (50 mg/kg; p.o. five times a week for two weeks) compares to SAHA-treated and control mice with similar toxicity^[1].

Animal Model:	8-week-old fvb mice^[1]
Dosage:	50 mg/kg
Administration:	Oral gavage; 50 mg/kg five times per week; for 2 weeks
Result:	Compared to both SAHA-treated and control mice with similar body weights and hematological counts.

分子量

390.22

Formula

C₁₄H₁₉IN₂O₃

CAS 号

1219807-87-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.